研究课题： 高分辨率荧光成像仪的研制与产业化，科技部重大科学仪器设备开发重点专项，2016.7-2020.6，子课题； 鞘氨醇激酶I在药物诱导的急性肝损伤和炎症中的分子机制研究，国家自然科学基金，2018/10-2021/12； 鞘氨醇信号对中枢神经系统炎症和免疫细胞招募调控机制的研究，国家自然科学基金， 2015/10-2018/12； 环境内分泌干扰物对女性生殖功能的影响及其分子机制，国家科技部重大科学研究计划（973）项目，2014/05-2018/6，2014CB943303-1； 补体成分C3、C5介导中枢神经系统炎症中血管内皮激活和中性粒细胞招募，国家自然科学基金，2013/10-2017/12； 中枢神经系统炎症状态下补体C3和C5对中性粒细胞招募的影响，教育部博士学科点基金（博导类）， 2013/11-2016/12； 活体显微镜研究CXC趋化因子在CNS中招募中性粒细胞，国家自然科学基金，2011/10-2015/12。
论文发表： Shi D, Tian T, Yao S, Cao K, Zhu X, Zhang M, Wen S, Li L, Su D, Shi MQ, Zhou H* FTY720 attenuates behavioral deficits in a murine model of systemic lupus erythematosus. Brain Behav Immun. 2018 Mar 13. pii: S0889-1591(18)30057-6 Cao K, Liao X, Lu JH, Wu FJ, Zhu X, Shi D, Wen S, Liu L Zhou H*IL-33/ST2 plays a critical role in cerebral endothelial cell activation and microglia-mediated neuroinflammation modulation. J Neuroinflam. 2018 May 4;15(1):136. doi: 10.1186/s12974-018-1169-6. Xu C, Zhang C, Ji J, Wang C, Yang J, Geng B, Zhao T, Zhou H, Mu X, Pan J, Hu S, Lv Y, Chen X, Wen H, You Q.* CD36 deficiency attenuates immune-mediated hepatitis in mice by modulating the proapoptotic effects of CXCL10. Hepatology 2017 Dec 8. doi: 10.1002/hep.29716. [Epub ahead of print]. Zhao Y, Shi D, Cao K, Wu F, Zhu X, Wen S, You Q, Zhan保存g K, Liu L, Zhou H* Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system. J Leuk Biol. 2018 Jan;103(1):107-118. Li X, Liao X, Zhang J, Wang Y, Wei P, Wu F, Shi D, Liu L, Ye N, Zhou H* Bisphenol A affects trophoblast invasion by inhibiting CXCL8 expression in decidual stromal cells. Mol Cell Endocrin. 2017 Jul 20. (17)30390-8. Wu F, Liu L, Zhou H* Endothelial cell activation in inflammation of central nervous system. J Leuk Biol. 2017 May; 101(5):1119-1132. Sun D, Zhang M, Liu G, Wu H, Li C, Zhou H, Zhang X, Shi M*. Intravascular clearance of disseminating Cryptococcus neoformans in the brain can be improved by enhancing neutrophil recruitment in mice. Eur J Immunol. 2016 Jul;46(7):1704-14. Wu F#, Zhou Q#, Ding X, Shi DY, Zhu X, Hu W, Liu L, Zhou H* Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain. J Neuroinflam 2016 Jan 28;13(1):23. doi: 10.1186/s12974-016-0485-y. Comments on “Focus on Complement” (International Complement Society) March 1, 2016 Zhu XX, Shi D, Li XQ, Gong WJ, Wu FJ, Guo XJ, Xiao H, Liu L, Zhou H* TLR signaling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α. Cell Signal. 2016 Mar;28(3):148-156. Zhang MS#, Sun DL#, Liu GG, Wu H, Zhou H, Shi MQ* Real-time in vivo imaging reveals the ability of neutrophils to directly remove Cryptococcus neoformans from the brain vasculature. J Leuk Biol.2016 Mar;99(3):467-73. Li L#, Wang Y#, Gao W, Yuan C, Zhang S, Zhou H, Huang M, Yao X*. Klotho reduction in alveolar macrophages contributes to CSE-induced inflammation in chronic obstructive pulmonary disease. J Biol Chem.2015 Nov 13;290(46):27890-900. Wu F, Zhao Y, Jiao T, Shi D, Zhu X, Zhang M, Shi M, Zhou H* CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation. J Neuroinflam 2015 May 21;12(1):98. doi: 10.1186/s12974-015-0316-6. Langer HF#,*, Choi EY#, Zhou H, Schleicher R, Chung KJ, Tang Z, Göbel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, Qu H, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T. Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res. 2012, 110(9):1202-1210. Shi M, Li S, Zheng C, Jones GJ, Kim KS, Zhou H, Kubes P, Mody CH*. Real-time imaging of trapping and ureasedependent transmigration of Cryptococcus neoformans in mouse brain. J Clin. Invest. 2010, 120(5): 1683-1693. Lee WY, Moriarty TJ, Wong CH, Zhou H, Strieter RM, van Rooijen N, Chaconas G, Kubes P*. An intravascular immune response to Borreliaburgdorferi involves Kupffer cells and iNKT cells. Nat. Immunol. 2010, 11(4):295-302. Zhou H, Andonegui G, Wong CH, Kubes P*. Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation. J Immunol. 2009, 183(8): 5244-5250. Andonegui G#, Zhou H#, Bullard D, Kelly MM, Mullaly SC, McDonald B, Long EM, Robbins SM, Kubes P*. Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J Clin Invest. 2009, 119(7): 1921-1930. Research highlighted in Nat Rev Immunol. Aug. 2009, 9:532 Zhou H, Lapointe BM, Clark SR, Kubes P*. A requirement for microglial TLR4 in leukocyte recruitment into brain in response to LPS. J Immunol. 2006, 177(11):8103-8110.
|
|
