Latest Research
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18 Apr
Chunlai Chen’s group develops chemi…
Cyclic GMP-AMP synthase (cGAS) plays a pivotal role in the cGAS-STING pathway as a DNA sensor that binds to double-stranded DNA (dsDNA) and subsequently induces type I interferon expression, thereby contributing significantly to the innate immune response. Dysregulation of intracellular cGAS has been strongly implicated in a number of diseases, and understanding the mechanisms that control cGAS...
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18 Apr
Chen Zhucheng's team captures dynami…
Nucleosomes, which consist of DNA wrapped around histone octamers, are the fundamental building blocks of chromatin. Chromatin remodelers utilize energy from ATP hydrolysis to reposition nucleosomes, thereby regulating chromatin structure and gene activity. Chromatin remodelers are divided into four major subfamilies: SWI/SNF, ISWI, CHD, and INO80, each having distinct biological functions. Amo...
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11 Apr
Hong-Wei Wang’s Team at Tsinghua Univ…
RNA interference (RNAi), a highly conserved RNA silencing mechanism, plays pivotal roles in gene expression regulation, antiviral defense, and genome protection against transposon activity. Compared to the well-characterized small RNA interference pathways mediated by microRNAs (miRNAs) and exogenous small interfering RNAs (exo-siRNAs), current understanding of the processing, maturation, and f...
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11 Apr
Song-Hai Shi’s Group at the School of…
Animals endure many physical and social stressors throughout their lifetime and have evolved crucial mechanisms to cope with these challenges. The brain is one of the primary organs involved in perceiving and adapting to various stressors. However, it remains unclear how neurons initially sense stress or which downstream signaling pathways drive behavioral responses. Addressing these questions ...
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11 Apr
Xiaofeng Fang’s Team at Tsinghua Univ…
Global warming poses a severe threat to crop productivity by inhibiting photosynthetic efficiency under heat stress, yet the molecular mechanisms remain poorly understood. On March 22, 2025, a groundbreaking study led by Dr. Xiaofeng Fang’s group at the School of Life Sciences, Tsinghua University, published in Nature Communications, uncovers how the chloroplast-localized MORF8 protein forms s...
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10 Apr
Yiguo Wang’s Group Unveils the Mechan…
Restrictive diets and regular exercise are cornerstone strategies for improving metabolic health and addressing chronic metabolic disorders such as obesity, type 2 diabetes, and sarcopenia. Despite their well-documented benefits, the shared molecular pathways underlying these interventions remain elusive.On January 2, 2025, Professor Yiguo Wang’s laboratory at the School of Life Sciences, Tsin...
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10 Apr
Research Team Led by Yiguo Wang and Co…
Glucose homeostasis requires precise regulatory mechanisms to adapt to varying physiological conditions such as feeding, fasting, exercise, and stress. Glucagon, a hormone secreted by pancreatic α-cells, plays a crucial role in raising blood glucose levels during fasting. Despite being discovered over a century ago, the mechanisms underlying glucagon secretion have largely remained unclear—un...
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10 Apr
Research Team Led by Yiguo Wang and Co…
The maintenance of glucose homeostasis is vital for survival and overall health. Although blood glucose levels in mammals fluctuate during feeding and fasting, they are typically maintained within a remarkably narrow range of 4–7 mM. This precise balance is achieved through the coordinated actions of multiple tissues. While numerous hormones that stimulate glucose production have been identifi...
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21 Jan
Jun-Jie Gogo Liu and Chunlai Chen from…
The CRISPR-Cas system has become one of the most widely used tools in gene editing, allowing precise targeting and cleavage of DNA through RNA-guided Cas proteins. Recent advancements in bioinformatics and biochemistry have significantly expanded our understanding of the diversity within CRISPR systems, particularly in type V, which rely on the highly conserved RuvC nuclease domain for target c...
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30 Oct
Guangshuo Ou’s Group at the School of…
Dynamic properties are essential for microtubule (MT) physiology, which depend on the polymerization and spontaneous depolymerization of tubulin isotypes at the MT ends. Mutations in tubulin-coding genes cause human diseases collectively designated as ‘tubulinopathies’. As a result, live-cell imaging of tubulins is crucial for understanding the dynamic regulation of MTs and elucidating their ...